Mohtasham Hina, Ammara Rasheed, Maria Tasleem, Nadia Naseem.
Protective effect of coriandrum sativum L. (coriander) ethanolic leaf extract on isoniazid induced hepatotoxicity in albino mice hepatoprotective effect of coriander.
Pak Postgrad Med J Jan ;32(3):124-8.

Objective:  To study the antioxidant effects of ethanolic extract of coriander leaves on INH induced hepatotoxicity. Methods: Total 27 male albino mice were randomly divided through balloting into three groups containing nine animals each. Group A served as control while INH toxicity was produced by oral administration (INH 100mg/kg) to group B. Hepatoprotectivity was investigated by co-administration of single oral dose of ethanolic extract of coriander leaves (200mg/kg) along with INH in groups C for 30 days. Results: On gross examination, liver of group C animals were found to be normal. Biochemical analysis of liver markers of group B showed that these enzymes were markedly raised while experimental group C showed significant decreased level of liver enzymes. Histological examination of group C revealed normal histology with little evidence of inflammation, vascular congestion, necrosis, pyknosis, apoptosis and vacuolar degeneration as compared to group B.   Conclusion: This study showed the ameliorating effect of ethanolic extract of Coriandrum sativum L. against INH induced hepatotoxicity.

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