Somasekhar R Menakuru.
Current management of Peptic Ulcer Perforations.
Pak J Med Sci Jan ;20(2):157-63.

Perforation is a life-threatening complication of peptic ulcer disease. The management of peptic ulcer disease has evolved over the decades, due to advances in operative techniques, bacteriology and pharmacology. While the recognition of the role of Helicobacter pylori (H. pylori) in peptic ulceration has resulted in a paradigm shift in the management of uncomplicated peptic ulcers, debate continues about the appropriate management of perforated duodenal bulb and prepyloric ulcers. A new dimension has been added to this controversy by the advent of laparoscopic techniques for closing the perforation. A medline search of all articles dealing with the management of peptic ulcer perforation published after 1985 was undertaken. The shortlisted articles were analysed and studies which were well designed and had important inferences were selected. Based on these inferences, the controversies surrounding the management of peptic ulcer perforation have been discussed in this review article.

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