Shoaib Malik, Maida Muzaffar, Nadeem Munir, Shahneela Raza, Lal Rehman.
Comparison of hemodynamic responses by IV labetalol and IV lidocaine at the time of tracheal extubation: a randomized controlled trial.
Pak J Surg Jan ;38(1):35-40.

Objective: The aim of this study is to compare the hemodynamic responses caused by labetalol and lidocaine during tracheal extubation. Study design: Randomized controlled trial. Place and duration of study: Jinnah Postgraduate and Medical Center, Karachi, from 5th September 2018 to 4th March 2019. Material and Methods: This was conducted in neuro-surgical operative rooms. A total of 124 patients undergoing craniotomies for space-occupying lesions under general endotracheal tube anesthesia of age between 18-65 years of either gender were included. Patients with sinus bradycardia or heart block, congestive heart failure, and asthma were excluded. All patients had their pre and post-operative vital signs (BP, HR, and MAP) recorded. Upon discontinuation of the inhalational agent bolus of labetalol 0.1mg/kg or lidocaine (1.5 mg/kg) was given intravenously. Patients were followed for at least 30 min post-operatively. Results: It was found that in group-A (IV lidocaine), the mean change in HR was 22.60+-9.09, SBP of 20.96+-10.53, DBP of 12.81+-7.24, and MAP of 14.44+-7.14 while in group-B (IV Labetalol), the mean change in HR was 24.11+-0.12, SBP of 20.95+-9.87, DBP of 12.13+-5.31 and MAP of 13.37+-5.26. Both groups have shown a significant reduction in mean hemodynamic parameters within groups. There is statistically significant reduction in heart rate in group-A (p-value= 0.0001) however for other hemodynamic parameters the difference between the two groups was not statistically significant. Conclusion: This study concluded that mean changes in the hemodynamic responses by IV labetalol are not statistically different

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