Rabbia Zubair, Masoom Raza Mirza, Muhammad Ali Channa, Uzair Yaqoob.
Comparing the effects of Ketorolac and Ibuprofen on postoperative pain relief after para umbilical hernia repair. a randomized clinical trial.
Pak J Surg Jan ;38(1):13-7.

Objective: To compare the effects of Ketorolac and Ibuprofen on post-operative pain relief aft er Para umbilical hernia repair. Study design: Randomized clinical trial. Place and duration of study: General Surgery Department of Hamdard University Hospital (HUH) Karachi, Pakistan from September 2016-December 2019. Material and Methods: Patients were selected by non-purposive convenience sampling. 60-patients underwent Mesh repair for para-umbilical hernia under general anesthesia are included and divided into two equal groups. Patient with ASA 1 and 2 are included. Age range is 18 years and above. Patients received either 30 mg ketorolac or 800 mg ibuprofen diluted in 200 mL normal saline in a double-blind, randomized fashion, administered over 30 min, in the post-anesthesia recovery unit started within 30 min of skin closure, followed by three additional doses every six hours. Results: There was no significant difference found between the two groups with mean VAS scores of 33.83+-9.06 and 33.00+-7.61 after six hours of surgery in the Ibuprofen and Ketorolac groups respectively. Both drugs were found to be effective since the mean pain intensity scores were 5.67+-4.49 and 6.83+-5.17 respectively. Rescue analgesia (Intravenous Tramadol 50mg) was opted for 17 patients in the Ibuprofen group and 25 in the Ketorolac group, where the difference was statistically significant (p=0.024) Conclusion: We concluded that there is no difference in post-operative analgesia provided by both drugs. Ibuprofen showed decrease requirement of rescue analgesia as compared to Ketorolac.

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