Farrukh Saeed, Muhammad Asif Siddiqui, Tayyaba Khawar Butt, Sikandar Hayat, Muhammad Azhar Farooq, Shagufta Niazi.
Role of Inhaled Budesonide in Transient Tachypnea of Newborn in Low-Income Country.
Pak Paed J Jan ;46(2):176-80.

Objective: To evaluate the role of budesonide in managing the transient tachypnea of newborn (TTN). Study Design: A prospective placebo-controlled non-randomized controlled trial. Place and Duration of Study: Department of Neonatology, Services Hospital, Lahore Pakistan from July 2021 to June 2022. Material and Methods: There were total 100 neonates, 50 in each group within 6 hours after birth, fulfilling the operational definition of TTN. The 1st group (steroid group) was given budesonide 2 ml via nebulization, while other group received 2 ml of distilled sterile water via inhalation. Neonates of both groups were evaluated and compared after 3 days of treatment for clinical outcomes like down score, TTN score, SpO2%, pH, and continuous positive airway pressure (CPAP). Results: Among 100 neonates with TTN, 51 (51.0%) were male. Mean gestational age and birth weight was 38.5 +- 2.0 weeks and 2.4 +- 0.5 kg respectively. After 3 days of treatment in both groups, steroid group was significantly better in comparison to control group in terms of TTN scores and Downs scores {TTN scores (2.2 +- 0.8 vs. 2.8 +- 1.0, p=0.0013), and down scores (3.5 +- 0.5 vs. 4.4 +- 0.9, p<0.0001)}. Conclusion: Treatment of inhaled budesonide showed improvement in respiratory rate and respiratory distress in our study.

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