In this ever growing high tech world of diagnostics, we have tried to introduce in our study a new parameter (Fibrinogen levels) as the cause of coronary artery disease. It was a cross-sectional survey of 100 normal individuals and 300 ischemic heart disease patients either admitted or as outdoor patients at AFIC/NIHD Rawalpindi. All individuals were tested for following investigations: Complete blood counts, Lipid Profile (Fasting), Blood Sugar (Fasting), Coagulation Profile (PT; PTTK etc), and Plasma Fibrinogen levels. Amongst 300 patients, 265 cases were male and 35 were female. One hundred & sixty seven cases (55.6%) had fibrinogen levels above 400mg/dl. (Normal range: 200-400mg/dl); 59 (35.3%) of then had fibrinogen levels even above 700mg/dl. One hundred & twenty three cases were smokers and out of these 97 individuals (78.86%) had raised fibrinogen levels. Similarly out of 76 diabetic patients, 65 (85.52%) had raised fibrinogen levels. Fifty seven patients had no known risk factor but 36 (63.1%) of them had hyper fibrinogenemia. Our study emphasizes the importance of hyper fibrinogenemia in the causation of coronary artery disease. Fibrinogen contributes in several ways in blood thickness and tendency to clot formation.
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