Nadia Sultan, Muhammad Usman Naeem, Khadija Mohsin, Saima Rehman, Ghazala Butt, Mahwash Rana.
Efficacy of intradermal tranexamic acid in melasma.
J Pak Assoc Derma Jan ;33(2):553-8.

Objective: To determine the efficacy of intradermal tranexamic acid (TA) in the patients of melasma.   Methods: This study was conducted in Dermatology OPD, Punjab Rangers Teaching Hospital over a period of 4 months from 14-08-2022 to 14-12-2022. A total number of 32 patients of melasma were enrolled after informed written consent. 2mL of concentrated tranexamic acid (50mg/ml) was injected intradermally, 1 ml on either side of face 1cm apart over the affected area.  A total of 4 sessions were carried out, followed after every 2 weeks. Results: were interpreted on the basis of MASI scoring before, during and after completion of the sessions. A mild topical steroid application was advised for 2 days. Sunscreen application was essentially prescribed.   Results:  Out of 32 enrolled patients of melasma, 56% showed 61-100% reduction in MASI scoring, which constituted a majority.   Conclusion: We concluded that un-diluted intra dermal tranexamic acid is an excellent treatment modality for treatment of melasma without any side effects.  

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