Mahboob Ahmed Wagan, Rashid Ahmed Shaikh, Syed Saud Hasan, Muhammad Baqir Soomro, Shaheen Shah.
Aminoglycosides; toxicity of once a day dosing.
Professional Med J Jan ;11(1):53-6.

Aminoglycosides are unique protein synthesis inhibitors and are bactericidal. Instead of three times a day, we gave gentamicin 3 mg/kg once a day, to 10 young patients, whose urine culture report showed sensitivity to gentamicin. They have an average age of 27 ± 6.5 years. The youngest patient was 19 years old and oldest was 37 years old, having normal creatinine clearance. There was no significant (P>0.05) change in renal creatinine clearance before and after 7 days of therapy.

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