Khushbu Lohana, Shahzaman Memon, Shafqat Hussain Khuwaja, Waqas Iqbal, Hafiz Mahmood, Farha Tasleem.
Association of E-Cadherin expression with different histopathological grading of Oral Squamous Cell Carcinoma (OSCC) in Hyderabad Sindh.
Professional Med J Jan ;30(09):1162-7.

Objective: To evaluate association of E-cadherin with different histopathological categorizing of oral squamous cell carcinoma in Hyderabad region. Study Design: Cross-sectional study. Setting: Branch of Oral Operation and Oral Pathology, Isra Dental College (IDC) Hyderabad. Study Period: 25th November 2021 to 25th November 2022. Material & Methods: Total 58 patients of OSCC and 10 normal mucosa samples were enrolled in this study, patient`s age, gender, habit and site of lesion was recorded on proforma. Total 68 paraffin embedded tissue fragments were processed discolored with Eosin & Hematoxylin stain. Further the tissue sectors stood immune-stained with E-cadherin and slide evaluated by pathologists. Results: Total 58 diagnosed patients of OSCC were characterized into three collections well distinguished, discreetly discriminated and unwell categorized OSCC. Total 46 (79%) were male and 12 (21%) were female. The cruel age of a female to male was 36.14 VS 43.21 years. Study reported decrease level of E-cadherin appearance with increasing "histopathological grading of OSCC", expression of E-cadherin was high in well distinguished OSCC trailed by moderately discriminated OSCC and poorly discriminated OSCC. Conclusion: Conclusions of the learning Reduced E-cadherin transcript has been linked to greater intrusiveness and metastatic spread in many malignancies, which include oral cancers. The level of E-cadherin expression recorded decrease with increasing severity and histopathological grading of OSCC. This would be proven a useful marker tool for the prediction of OSCC grading and oral cancers to metastasize, providing valuable information for cancer diagnosis and treatment planning.

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