Anees Fatima, Nishat Akram.
Fasting Lipid Profile in Pregnant patients as a Predictor of Gestational Diabetes Mellitus.
J Sharif Med Dent Coll Jan ;9(1):17-21.

Objective: To predict the risk of developing gestational diabetes mellitus (GDM) in early pregnancy by comparing the fasting lipid profile in pregnant patients with or without gestational diabetes during the second trimester of pregnancy. Methodology: It was a cross-sectional study that was conducted in the Department of Gynecology & Obstetrics, Sharif Medical City Hospital, Lahore for six months from January to June 2021. A total of 385 patients were enrolled in the study. Out of 385 patients, 210(54.5%) women were with gestational diabetes mellitus (group A) and 175(45.5%) were without GDM (group B). A fasting lipid profile was performed by taking blood samples of patients. All samples were assessed for levels of total cholesterol (TC), triglyceride (TG) concentrations, low-density lipoproteins (LDL), and high-density lipoproteins (HDL). Results: The mean age of the patients was 27.5+/-4.2 (group A) and 26.7+/-4.2 years (group B), respectively. The body mass index (BMI) was 29.4+/-3.6 in group A versus 25+/-3.5 in group B. The mean lipid profile in group A versus group B was; TC (177.1+/-21.3 versus 136.5+/-29.6, p <0.001), TG (186.3+/-23.9 versus 131.1+/-30.4, p <0.001), LDL (140.3+/-19 versus 96.3+/-23.1, p <0.001), and HDL (40.9+/-4.6 versus 44.3+/-23.9, p=0.044). Conclusion: Hyperlipidemia is associated with GDM and identifies the need to evaluate maternal lipid profile in women with gestational diabetes mellitus during the antenatal period. Keywords: Gestational diabetes. Cholesterol. Triglyceride.

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