Sundus Nasim, Abdul Haseeb, Hassan Atique, Muaz Mubashir, Mehdi Hassan Naqvi, Ahmed Ali Wassan.
Diagnostic Accuracy of Serum Uric Acid in First Trimester of Pregnancy for the Diagnosis of Gestational Diabetes Mellitus.
J Sharif Med Dent Coll Jan ;9(2):81-5.

Objective: To assess the diagnostic accuracy of elevated uric acid in the first trimester of pregnancy for the diagnosis of gestational diabetes mellitus (GDM) keeping the oral glucose tolerance test as the gold standard. Methodology: This cross-sectional study was done at the Department of Gynaecology & Obstetrics, Islamabad Medical Complex, NESCOM, Islamabad after ethical approval. A total of 455 booked pregnant females presenting within the first trimester were enrolled using non- probability convenience sampling technique. All participants were included after taking informed consent. Their blood sample was taken for uric acid analysis. Females were labeled as having normal (=<3.4 mg/dL) and high uric acid (>3.4 mg/dL). During 22-24 weeks of pregnancy, an oral glucose tolerance test (OGTT) was performed for diagnosing GDM. Data was analyzed using the Statistical Package for the Social Sciences (SPSS) version 25. Results: In our study, 198(43.5%) pregnant females had GDM. Among the patients with GDM, 147(74.2%) of them had high uric acid level, with a significant association (p-value=0.00001). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), negative likelihood ratio (LR-), and diagnostic accuracy of first trimester high uric acid keeping OGTT as the gold standard were 74.24%, 87.94%, 82.58%, 81.59%, 6.2, 0.29, and 81.98%, respectively. Conclusion: The high uric acid level in the first trimester is a significant predictor of gestational diabetes mellitus with a diagnostic accuracy of 81.98%. Keywords: Gestational diabetes mellitus. Uric acid. Oral glucose tolerance test.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com