Muhammad Ahmad, Irfan Rasool, Madiha Rauf, Muhammad Shahbaz, Muhammad Imran, Waleed Tariq.
Correlation between Mean Serum Uric Acid Level and Left Ventricular Diastolic Dysfunction in patients with Chronic Kidney Disease.
J Sharif Med Dent Coll Jan ;9(2):46-50.

Objective: To assess the correlation of mean serum uric acid (UA) level as a predicting tool for left ventricular diastolic dysfunction (LVDD) in patients with chronic kidney disease (CKD). Methodology: A cross-sectional, analytical study was conducted at the Nephrology Department, Allied Hospital, Faisalabad from March to October 2021, using non-probability consecutive sampling method. The patients aged between 20-50 years having grade 2 to 5 CKD and left ventricular ejection fraction >50% were included in this research. The blood sample was withdrawn from each participant and serum UA level was measured through the Uricostat enzimatico method by a mono-reagent technique using a Selectra ProXL device. Pulsed wave tissue Doppler echocardiography was performed using an Esaote SpA device with a 2.5-3.5 MHz transducer to assess the LVDD. Results: A total of 40 cases were included with a mean age of 42.48+/-6.96 years. Twenty one (52.5%) were males and 19(47.5%) were females. The mean serum UA level and mean peak early diastolic velocity (EmLV) were 6.49+/-0.56 mg/dL and 6.45+/-2.85 cm/sec, respectively. The LVDD was recorded in 31(77.5%) patients. A significant negative correlation was found between mean serum UA level and LVDD in patients with CKD (r-value=-0.846, p-value=0.0001). Pearson correlation between mean serum UA levels and LVDD in the higher age group (36-50 years) was negative (r-value=-0.8476, p-value=0.001). Similarly, the female gender had a negative correlation between mean serum UA levels and LVDD (r-value=-0.9029, p-value=0.001). Conclusion: The left ventricular diastolic dysfunction in CKD patients can be predicted by elevated serum UA levels. So, uric acid can be used as a screening tool for LVDD in CKD patients. Keywords: Chronic kidney disease. Ventricular dysfunction. Uric acid.

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