Faiza Hanif, Nadira Mamoon, Zafar Ali.
Arginase-1 Immunohistochemical Staining in Hepatocellular Carcinoma.
J Sharif Med Dent Coll Jan ;8(2):72-6.

Objective: To determine the immunohistochemical expression of arginase-1 in different grades of hepatocellular carcinoma (HCC). Methodology: It was a cross-sectional study conducted at the Pathology Department of Shifa International Hospital, Islamabad, commencing from September 2018 to July 2019. Arginase-1 immunohistochemical stain was performed on 70 cases of hepatocellular carcinoma. Information regarding patient age, gender, histological grade of tumor, and expression of arginase-1 on hepatocellular carcinoma cases were recorded on a proforma sheet. Results: A total of 70 cases were included in the study. The arginase biomarker was positive in 65(92.9%) cases and negative in 5(7.1%) cases. Out of these, 7(87.5%) out of 8 cases were well differentiated, 47(95.9%) out of 49 cases were moderately differentiated, and 11(84.6%) out of 13 cases were poorly differentiated HCCs. Out of a total of five cases which did not show arginase reactivity, 1 was well differentiated, 2 were moderately differentiated, and 2 were poorly differentiated HCCs. The distribution of arginase immunostaining among different histological grades showed no statistical significance (p=0.458). Conclusion: Arginase-1 has a high sensitivity for hepatocellular carcinoma. It has a high sensitivity for well and moderately differentiated HCCs as compared with poorly differentiated HCCs. Keywords: Arginase. Hepatocellular carcinoma. Immunohistochemical markers.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com