Sarah Saleem, Sarwat Jahan, Aamna Khokhar, Mehreen Mirza, Salman Zahir.
Comparison of the Efficacy of Combined Therapy with Oral Tamsulosin Plus Oral Diclofenac and Tamsulosin Alone in Time & Rate of Expulsion of Distal Ureteric Stones.
Ann Pak Inst Med Sci Jan ;19(4):419-23.

Objectives: To compare the effectiveness of combined therapy with Tamsulosin and Diclofenac sodium and Tamsulosin alone in the rate and time of expulsion of distal ureteric stones of size ranging from 5-<9mm. Methodology: This randomized clinical trial study was conducted at Benazir Bhutto Hospital Rawalpindi and Institute of Kidney Diseases-Hayatabad Medical Complex Peshawar from December 2019 to December 2020. All male and female patients presenting to the urology OPD diagnosed with unilateral distal ureteric stones on X-ray KUB were recruited using systematic random sampling and divided into two groups: Group A (study group) and Group B (control group). Patients with odd numbers were assigned to Group A, while those with even numbers were assigned to Group B. Group A received Tab. Tamsulosin 0.4mg OD and Tab. Diclofenac sodium 75mg BD for 21 days. Group B received Tab. Tamsulosin 0.4 mg OD for 21 days and acetaminophen 500mg SOS. Results: The clinical trial revealed that in the group of patients receiving Tamsulosin and diclofenac, the rate of expulsion of distal ureteric stones was improved with a statistically significant difference. Time of expulsion of stones in two groups wasn’t statistically different. Conclusions: Tamsulosin and Diclofenac sodium given together have added effect /benefit as compared to Tamsulosin alone in the rate and time of expulsion of distal ureteric stones.

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