Rana Tariq Mahmud, Hidayat Hussain Khan, Janbaz Ahmad.
Effects of Cimetidine, Ranitidine and Tiotidine on Spermatogenesis in albino rats.
Professional Med J Jan ;3(2):133-6.

The effects of cimetidine, ranitidine and tiotidine were studied on spermatogenesis in adult male albino rats after administering these drugs at the dose levels of 5.71 mg/kg, 2.14 mg/kg and 1.42 mg/kg body weight respectively twice daily for a period of five weeks. The results showed that cimetidine and tiotidine caused a significant decrease (P < 0.05) in the number of spermatocytes. However cimetidine and tiotidine produced a marked decrease (P < 0.05) and (P < 0.001) respectively, in the number of total germ cells in the seminiferous tubules. It is conceivable that ranitidine also possess antipermatogenic activity, which was not found out in previous research work.

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