Tufail Muhammad, Abdul Hafeez, Naeem Ahmad, Janbaz Ahmad.
Prevalence of idiopathic Hypercalciuria and Hyperuricoseuria in primary calcium stone formers and beneficial role of low dose Asprin.
Professional Med J Jan ;3(1):51-8.

The calcium stones are the most common renal stones throughout the world. Idiopathic hypercalciuria is the most common metabolic abnormality (30-60%) and hyperuricoseuria is next common (26.3%). OBJECTIVES: 1. To compare the international data on the prevalence of idiopathic hypercalciuria and hyperuricoseuria with local population. 2. To assess the beneficial effect of low dose aspirin in controlling hyperuricoseuria. DESIGN: prospective study. SETTING: Allied Hospital Faisalabad. PERIOD: Feb 1991 to June 1993. SUBJECTS: One hundred twenty eight patients (92 males and 36 females) suffering from renal colic or stone disease without any secondary cause of urinary stone. METHODS: Complete clinical data, urine analysis and estimation of 24 hours urinary calcium, uric acid and magnesium was performed. Seum urea, creatinine, calcium, phosphorus, and electrolytes estimation was also performed. X-ray chest, abdomen and ultrasound was carried out. Low dose aspirin (150 mg per day) was given for three weeks and investigations were repeated. PARAMETER: Hypercalciuria was defined as 24 hours urinary calcium >220 mg in males and >180 mg in females and hyperuricoseuria as urine uric acid >500 mg in males and >480 mg in females. RESULTS: Isolated hypercalciuria was seen in 19.5% males and 19.5% females. Isolated hyperuricoseuria was seen in 55.4% males and 50% females. 15% male and 1%, females had both abnormalities 25% males and 30% females did not have any abnormality. CONCLUSIONS: The prevelance of hypercalciuria (19.5%) is significantly lower while hyperuricoseuria level (50-55%) was significantly higher in our population. Magnesium deficiency was not a contributory factor in our population. Aspirin 150 mg per day has shown a significant beneficial effect in lowering urinary uric acid level.

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