Nasir Khokhar, Mansur Basharat Butt, Muzaffar Lateef Gill.
Successful treatment of resistant chronic Hepatitis C virus infection with high dose Pegylated Interferon.
J Coll Physicians Surg Pak Jan ;15(1):41-2.

We present the case of a 49 years old male, who was HCV RNA positive with an ALT of 260, showing no response to standard interferon (INF) plus ribavirin treatment for 48 weeks and to a further therapy with high dose standard IFN plus ribavirin for 24 weeks. Pegylated (PEG) IFN was then started at a dose of 80mcg/week with ribavirin, but proved to be of no avail. Finally, a dose of 120mcg/week of PEG INF and ribavirin was administered for 48 weeks. This resulted in negative HCV RNA PCR after two months and remained undetectable with normal ALT. A six-month follow-up showed a sustained viral response.

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