Fazlur Rahim, Muhammad Younas.
Malaria in children: clinical profile and response to treatment. A district level experience.
J Med Sci Jan ;11(1):21-5.

Malaria affects about 300 million people and causes more than a million deaths per year worldwide. This study comprising of 50 cases of malaria in children was conducted at Tehsil Head Quarter Hospital, Tangi, District Charsadda. The purpose of this study was to evaluate the clinical profile and response to different antimalarial drugs. Fever was the clinical presentation in 100% of cases and chills and convulsions in 20% each. Herpes labialis and jaundice were present in 20% and 10% of cases respectively. Anemia and spleenomegaly was found in 20% of cases. Quinine was the most effective drug followed by amodiaquine, halofantrine (half an) and quinine plus fansidar in combination. Chloroquine was not used in this study because of its emerging resistance shown in different studies. Resistance to amodiaquine was found in 37.50% while least resistance 06.60% was observed with halofantrine. None of patients were found to be resistant to quinine and fansidar in combination.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com