Masood Ahmed Zakai, Syed Moin Ali, Mansoorul Aziz, Tauqeerul Islam.
Etiology of Oral cancer/ Squamous Cell carcinoma in oral cavity.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;8(1):48-52.

Objective: The purpose of this study on squamous cell carcinoma (SSC) in oral cavity was to: • Evaluate the association between various risk factors and SSC • Determine the pattern of clinical presentation Patients and Methods: Sixty consecutive new patients were recruited to study the above mentioned features in the oral cavity were included in this study. Inclusion criteria were biopsy proven SSC of any age and gender involving anterior oropharyngeal part. Exclusion criteria were SSC cases with prior surgery recurrence or post radiated patients and chemotherapy. Results: In this study of 60 patient, there is a light pre-ponderance of male, female ratio of 1:3. average age cases was 49.47 + 9.28 (SD) Buccal mucosa was involved in 46.6% cases being the most common followed b mandibular alveolar mucosa and retromolar trigone area. Among the relevant chewing and smoking habits pan with tobacco was pre dominant 76.7% followed by cigarette smoking and Areca nut (supari-chahlia). Leukoplakia (40%) being the most frequently associated pre-malignant disease. Ulceration and exophytic growth combined were seen together in 47% of cases. Conclusions: Buccal mucosa is the most common site involved in SSC. Pan and tobacco chewing was the most common habit among the sample, while ulceration being the most clinical presentation.

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