Virender Suhag, Vivek Kaushal, Sunita B S, Arun Joshi.
Cystic mesothelioma: Role of Tamoxifen in preventing recurrence in the post-operative setting.
Pak J Med Res Jan ;43(3):150-2.

Cystic mesothelioma is a rare benign tumor of the peritoneal cavity arising from mesothelial cells. It is characteristically found in women during the reproductive years. No more than 130 cases have been reported in the English literature so far. Curative resection is often required to establish diagnosis and also for definitive management. Local recurrences without distant metastases are a feature of this pathology, hence long term follow-up is necessary. Therapy with the antiestrogen tamoxifen in the post-operative settings may provide an option for long-term medical management in cases of symptomatic recurrent cystic mesotheliomas. Prognosis is good despite frequent recurrences. Here we present the case-report of a female with cystic mesothelioma who underwent surgical management, remained symptom-free for10 months, and then again started having similar symptoms as were present prior to surgery. The patient refused explorative second-look surgery. Thereafter, the patient has been put on Tab Tamoxifen 20 mg once daily, has responded well, and is subjectively and objectively disease- free since 24 months. Hence Tamoxifen may have a role not only in the treatment of symptomatic recurrent cystic mesothelioma, but also in preventing recurrences in selected cases.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com