Nadeem Baig, Nuzhat Hassan.
Effects of Estradiol and Tamoxifen on trabecular bone loss: a histomorphometric placebo-controlled study.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;8(2):444-9.

Objective: The present study was designed to evaluate the effects of Tamoxifen and Estradiol-valerate on trabecular bone loss in postmenopausal aged (15- 21 months) female albino rats. Setting: Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi Specimen: Ninety bones comprising femur, tibia, and humerus (30 each). Methodology: Histomorphometry used in which the width of trabeculae mapped out with the help of stage and ocular micrometer under low magnification of compound microscope. Results: The trabeculae of Tamoxifen treated groups appeared to be of increased thickness with more wellorganized pattern of arrangement as compared to other groups. Conclusion: Tamoxifen increases trabecular (cancellous) bone thickness in ageing female albino rats.

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