Saeed Eshraghi.
An evaluation of the potent inhibitory effects of Royal jelly fractions against Streptomyces bacteria.
Pak J Med Sci Jan ;21(1):63-8.

Objective: To investigate the anti-bacterial properties of royal jelly against six different bacteria (Escherichia coil, Staphylococcus aureus, Streptomyces griseus, and three unclassified strains of Streptomyces). Design: To find out the antibacterial properties of royal jelly by means of agar distribution method (drop-plate). Setting: The diameter of the clean zone formed in each concentration was measured and correlated to the ability of the extracts to inhibit the growth of microorganisms. Interestingly the results show inhibitory effects of royal jelly on different strains of the bacteria in-vitro. Four concentrations of water soluble extracts of pure royal jelly were prepared and added drop wise to the bacterial strains seed layer cultured individually. Main outcome measures: Ether-soluble and non-soluble fractions of the royal jelly were also examined using the above method. Results: It was found that the antibacterial effect of ether-soluble fraction is substantially higher than the effect of ether non-soluble fraction. The zones formed by ether-soluble fractions of royal jelly in the route of distribution in agar belong to the potency of anti-bacterial properties of fatty acids present in this fraction of royal jelly (10 -HDA). Conclusions: The non ether-soluble fraction of royal jelly contains a bactericidal substance called royalisin that was found to have potent antibacterial activity. This fraction of royal jelly revealed weaker antibacterial effect than the ether-soluble fraction and even of pure royal jelly. Hence apart from its nutritional and medicinal effects, royal jelly`s bactericidal ability should be considered and employed whenever appropriate in clinical medicine.

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