Azhar Mehmood Kayani, Azmat Hayat, Abdul Hameed Siddique.
Hypercholesterolemia and IHD - two years experience at Combined Military Hospital Multan.
Pak J Cardiol Jan ;16(1):35-40.

Hypercholesterolemia is a health risk, and a strong relationship between this and atherosclerosis has been established through epidemiological, experimental, and clinical trial data. We indented to reestablish this association in one of our local population. We followed 540 consecutive patients during two years period who were admitted to the medical units of combined military hospital Multan with ischemic heart disease (IHD). Mean age of the patients was 48.39±0.61 years, mean cholesterol 214.61±1.69 mg/dl, mean high-density lipids (HDL) 50.13±1.05 mg/dl, mean low-density lipid (LDL) 154.53±2.27 mg/dl and mean triglycerides (TG) 172.81± 3.63 mg/dl. Risk factors were recorded in 450 patients out of which hypertension was recorded in 120 (22.22%) patients, diabetes in 100 (18.51%) patients, family history of HID in 80(14.81%) patients while there were 150 smokers. There were 383(70.09%) male patients in whom the mean cholesterol was 213.32±2.26 mg/dl, mean LDL 151.39±2.79 mg/dl, mean HDL 49.16±1.00 mg/dl and mean triglycerides was 170.64±4.18 mg/dl. There were 157(29.10%) female patients in whom mean cholesterol was 222.94±5.07 mg/dl, mean LDL159.73±4.48 mg/dl, mean HDL 53.05±2.95 mg/dl and mean TG 178.81±8.33 mg/dl. 51(9.44%) patients (mean age 50.10±1.91) presented with acute myocardial infarction out which 43 were males and 8 females. Mean cholesterol in this group of patient was 221.36±3.70 mg/dl, mean LDL 155.17±3.28 mg/dl, mean HDL 52.09±1.22 mg/dl, mean TG 170.41±6.74 mg/dl. 22 (4.1%) patients (Mean age was 33.05±1.35) presented with unstable angina of which 13 were males and 9 females. In this group, mean cholesterol was 231.14 mg/dl, mean LDL 162.70 mg/dl, and mean HDL 42.86 mg/dl. It can be concluded from this study that hypercholesterolemia is associated with IHD and levels of cholesterol, low-density lipoproteins and triglycerides were higher than the desirable levels in our local population. Though the levels of the cardio protective HDL were also higher in our study group which was contrary to the common observation.

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