Background Cutaneous Leishmaniasis (CL) is endemic in certain areas of Pakistan. This study was carried out to determine the efficacy of intralesional chloroquine in CL. Patients and methods CL patients with single lesion presenting to Leishmaniasis clinic of Tehsil Headquarter Hospital, Sadda from 1st December, 2003 to 30thMarch, 2004 and subsequently to outpatient department of Hayatabad Medical Complex, Peshawar, were included in the study. The patients were diagnosed clinically and by laboratory confirmation of parasites in a Giemsa – stained smear prepared from the lesion. All important clinical details were recorded on a specially designed pro forma and patients were registered for the purpose of treatment and a card was issued to them for subsequent visits and follow up. Twelve atients were treated with intralesional chloroquine thrice weekly for three weeks. Results All patients were declared cured on the basis of clinical and pathological criteria at 7 weeks (4 weeks after the completion of therapy). No adverse effects were observed. Conclusion Intralesional chloroquine was found to be safe and cost-effective therapy for single lesion of cutaneous leishmaniasis. Intralesional chloroquine was used for the first time in the treatment of CL.
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