Ghulam Mujadid Qureshi, Ghulam Mustafa Seehar, Saeed Ahmed Sangi, Zafar Ali Pirzado.
Blood cholesterol in relation to hemodynamic reactivity under examination stress.
Professional Med J Jan ;11(3):294-300.

Objective: This study was a part of our major work, which was being conducted on hematological variations and hemodynamic changes among different study groups, selected from medical students (2001-2003) in order to interpret and establish a base line for understanding the physiological facts related to such variations and their co-relationship under stress. Design: In this study the participants were subjected to mental stress during degree examination for the analysis of changes in blood cholesterol, namely Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-C), and High Density Lipoprotein Cholesterol (HDLC) in relation with heart rate (HR), pulse rate (PR) , systolic & diastolic blood pressure ( SBP & DBP) responses. Venous blood samples were collected from the students in fasting condition along with estimation of all those cardiovascular responses during both, the stress period of examination & non-stress period of one and half month rest given to them, when there was no such serious academic activity. Results: The means and standard deviations of differences of stress and non stress conditions for all cholesterols and cardiovascular observations were evaluated by method of paired sample design. For the level of significance those results were analyzed by student`s -test and 95% confidence interval. Conclusion: It is concluded that the variations in TC, LDLC and HLD-C may be due to haemoconcentration under acute mental stress given to the subjects. As the findings were observed in the fasting group of the subjects, so such related facts regarding mechanisms affecting the variables of the cholesterols in relation with haemodynamic under stress changes have been discussed. However further studies may also be needed.

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