Syed Nayyer Mahmood, Muhammad Ali Afzal, Saman Zafar, Faisal Muhammad.
Successful treatment of Diabetes Insipidus with oral Desmopressin.
Rawal Med J Jan ;30(1):46-7.

A 37 year old male presented to our OPD with increased urinary frequency and thirst for last six months. He was urinating 13-14 times a day, 4-6 times at night, and consuming 30-40 glasses of water daily. The general and systemic examinations were unremarkable. His routine laboratory and radiological investigations were normal, except for a serum sodium concentration of 149mEq/L. Routine urine report showed a specific gravity of 1.003. Urine osmolality was 91mosm/l. Calculated serum osmolality was 288mOsm/L and spot urinary sodium was 70mEq/L. His water deprivation test was positive for positive for Cranial Diabetes Insipidus. The patient was placed on 0.2 mg of Desmopressin orally daily. His serum sodium after 72 hours was 143mEq/L, serum osmolarity was 280mOsm/L and urine osmolality was 235m Osm/L. On follow up 2 weeks later, he reported resolution of his initial symptoms. Serum sodium was 146mEq/L, serum osmolality was 288mEq/L and urine osmolality was 290mEq/L. MRI of brain was reported normal.

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