Muhammad Tayyab Ansari, Bashir Ahmed Loothar, Qasim Jahangir Khan.
Pharmacokinetic study about interaction of naproxen and Isoniazid.
Pak J Pharm Sci Jan ;12(1):27-32.

Effect of Naproxen (500 mg) was studied on the pharmacokinetic characteristics of Isoniazed (300 mg) in ten healthy human volunteers in a complete crossover design. A high performance liquid chromatography (HPLC) method was used to analyze serum drug concentrations. Naproxen caused a highly significant (P<0.00l) increase in AUC, significant (P<0.05) increase in elimination half life (t12) and time for the maximum drug concentration (tmax) while significant (P<0.05) decrease in elimination rate constant (Kc). Insignificant decrease and increase was observed in absorption rate constant (Ka) and maximum drug concentration (Cmax) respectively.

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