Sadqa Aftab, Razi Mohd, Saira Bokhari, Abdul Bari Khan.
Comparison of Fentanyl / Isoflurane versus Nalbuphine/Isoflurane in patients undergoing elective Coronary Artery Bypass Surgery.
Pak J Cardiol Jan ;16(2):83-9.

Objective: To compare hemodynamic stability, efficacy and extubation time by using fentanyl / isoflurane versus nalbuphine / Isoflurane for coronary artery bypass surgery. Design: Intervention experimental study. Place and duration of study: The Department of Anesthesiology and Surgical Intensive Care Unit, Dow Medical College and Civil Hospital, Karachi from April 2003 to April 2004. Methods: Sixty patients, both sexes, with ejection fraction not less than 40%, elective coronary artery bypass surgery were randomly allocated to receive either fentanyl / isoflurane or albuphine. Hemodynamic stability, drugs supplemented and extubation time were recorded. Results: During intubation, skin incision and sternotomy systolic blood pressure was 126,47±7.45,127.97 ± 7.58 and 127.03± 7. 10 in group A fentanyl/isoflurane) and 167.60 ± 14.41, 169.50 ± 12.99 and 165.83 ± 11.79 in group B nalbuphine/isoflurane) respectively with (p < 0.05) which is significant. To maintain hemodynamic stability in group B, supplementation with propofol and glyceryltrinitrate infusion was required. Extubation time in group A was 8.2113.87, and in group B was 6.15 ± 3.41 with (p<0.05) which is significant. Conclusion: Fentanyl/isoflurane provides better hemodynamic stability than nalbuphine / isoflurane, but nalbuphme / isoflurane leads to earlier tracheal extubation than fentanyl / isoflurane group.

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