Sajjad A Ansari, Saddique M, Waqar Azim.
Antibiotic prophylaxis in clean surgery.
Biomedica Jan ;21(2):121-4.

This study was performed to compare the use of perioperative prophylactic antibiotics in reducing wound infection in clean elective general surgery operations with no use of antibiotics in these operations. It was an experimental prospective study. The study was conducted at Combined Military Hospital (CMH) Multan from June 2002 to December 2002. Hundred patients were included in the study. Convenience sampling technique was used for the selection of patients. Only those patients undergoing clean elective general surgery operations were included. Patients were divided into two equal Groups (Group A and Group B). Those in Group A were given injection cephradine 1g IV 8 hourly and injection gentamicin 80 mg IV 8 hourly 30 minutes before operation and continued for 24 hours postoperatively. Patients of group B did not receive any antibiotics. Surgical technique employed was similar. Patients from both groups were observed for the presence of wound infection. It was observed that in Group-A (with chemoprophylaxis) one patient (2%) developed postoperative wound infection and in Group-B (without chemo-prophylaxis) three patients (6%) developed postoperative wound infection. The low frequency of postoperative wound infection seen in Group-A as compared to Group-B (1/50 Vs 3/50) was not statistically significant by Chi-Square test. This study concludes that routine perioperative antibiotic prophylaxis doesn`t significantly reduce the incidence of postoperative wound infections in clean elective general surgery operations.

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