Rehana Akhtar, Aslam Haider, Rare Raza.
Neonatal sepsis in NICU: bacterial isolates and their sensitivity pattern.
J Surg Pak Jan ;10(4):18-21.

Objective: To assess the prevailing pathogens and their sensitivity pattern to antibiotics in our Neonatal Intensive Care Unit ( NICU). Patients and Methods: This was a descriptive study carried out from 1st July 2004 to 30th June 2005, at National Institute of Child Health, Karachi. All the neonates admitted into NICU with strong suspicion of neonatal sepsis were included in the study. Results: A total of 687 cases with suspected sepsis were admitted and blood was sent for culture and sensitivity. Out of 687 cases, 319 (46.43%) were positive on blood culture. Frequent offenders were gram negative organisms 295 (92.48%). Out of 295 gram -ye blood culture, Enterobacter was the most common pathogen (52.88%, n=156), followed by Klebsiella (22.37%, n=66), Pseudomonas (21.0%, n=62), E.coli (2.0%, n=6), Citrobacater (1.35%, n=4) and Serratia. (0.33%, n=1). Among grams +ve organisms (7.52% n=24) Staph aureus was the main causative organism (n=17) followed by Streptococcus pneumoniae (n=4) and streptococcus spp (n=3). Conclusion: Multi-drug resistant gram -ve organisms are emerging as significant pathogens among cases of neonatal sepsis in our NICU.

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