Ghazala Hanif, Samina Zaman, Tahira Hamid.
Analysis of the Liver Biopsies: A Histopathological Study.
J Coll Physicians Surg Pak Jan ;11(8):505-7.

Objective: To evaluate the spectrum of childhood liver diseases. Design: A department-based retrospective study. Place and Duration of Study: It was carried out at the department of Pathology, Children`s Hospital and the Institute of Child Health, Lahore, over a period of two years (October 1998 to October 2000). Subjects and Methods: The histopathological data of total 50 percutaneous needle biopsies, wedge biopsies and partial hepatectomy specimens of both the sexes between 1 month - 16 years age were collected and compared with the findings reported from centers in other parts of the country. Results: The commonest cause of hepatomegaly was hepatic inflammatory disorder in 43 cases (29%) followed by biliary atresia in 40 cases (27%). Other causes of hepatomegaly were hepatic neoplasia 11 cases (7.3%), cirrhosis 10 cases (7%), glycogen storage disease 10 cases (7%) and fatty change in 8 cases (5.3 %). Conclusion: Hepatic diseases are quite common in paediatric population in Pakistan and percutaneous needle liver biopsy is an important and helpful diagnostic procedure in undiagnosed cases of hepatomegaly.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com