Mahmood Ahmad, Ruqaiya Hasan, Mansoor Ahmad.
Effects of prolonged administration of large doses of ACTH ON Bufo Melanostictus Tadpoles.
Pak J Physiol Jan ;1(1-2):7-10.

Background and Methods: The present study reports the effects of different ACTH preparations, in similar and different concentrations on Bofo Melanostictus Tadpoles. Results: ACTH administration proved antagonistic to tadpole growth hormone. There seemed to be no dose-effect. response when ACTH was administered in 0.02 IU/ml instead of 0.01 IU/ml. Similar ACTH concentrations with difference of manufacture showed varied biological potency. Conclusions: This perhaps indicates loss of effectiveness due to change from ACTH 1-24 to ACTH 1-18 to ACTH 1-10 in descending order.

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