S Motahir Ali Shah, Khem A Karira, Salahuddin.
Association of Lipoprotein(A) with Myocardial Infarction.
J Coll Physicians Surg Pak Jan ;11(6):374-8.

Objective/s: To compare serum lipid profile i.e., lipoprotein (a) [Lp (a)], total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) levels of subjects with and without history of myocardial infarction (MI) and to find out the association of Lp(a) with the development of coronary artery disease (CAD). Design: All the subjects were studied prospectively. Place and Duration of Study: Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. Subjects and Methods: Thirty subjects aged less than 50 years with the history of proven myocardial infarction were randomly selected as group A, from hospital record and were matched with subjects having no history of myocardial infarction, group B, to serve as control. Fasting blood samples of both the groups were collected and analyzed on Humalyser 2000 to measure Lp(a) while lipids and Lp variables were analyzed enzymatically. Results: Subjects with a history of myocardial infarction had a significantly higher level of serum Lp(a) (p<0.001) as compared to those without the history. The other lipoprotein variable which exhibited a significant difference between the two groups of subjects was HDL-C (P<0.001). Conclusions: The subjects with early myocardial infarction have higher mean values of Lp(a) than control subjects suggesting that this lipid variable may strongly predispose to CAD. Although a possible influence of other factors may account for part of this result, a genetic predisposition to CAD is also likely to be involved since Lp(a) levels are strongly determined genetically.

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