Abdul Majid, Imran Ahmad Qureshi, Muhammad Abid Nizamy, Noreen Akhtar, Noveen Akbar.
Inverse relationship between Ocular Pressure and Plasma Lipids in Ocular Hypertensive Pregnant Women.
Pak Armed Forces Med J Jan ;49(1):36-8.

During pregnancy, an increase in the levels of triglyceride, total cholesterol, low density lipoproteincholesterol (LDL-cholesterol), and high density lipoprotein-cholesterol, (HDL-cholesterol), and decrease in intraocular pressure (IOP) have been reported. Little attention has been focused on measurements of these parameters in ocular hypertensive subjects during pregnancy. After placing control on all the factors that can affect IOP, the present study investigated whether in ocular hypertensive subjects, the changes in lipids and IOP levels during pregnancy are related. IOP and concentrations of triglyceride, total plasma cholesterol, VLDL-cholesterol, LDL-cholesterol and HDL-cholesterol were determined throughout the pregnancy and in non-pregnant ocular hypertensive women. Compared to control group, concentrations of all plasma lipids increased significantly during second trimester and reached maximum in the third trimester of pregnancy. Maximal increases in the concentrations of triglyceride, total cholesterol, VLDL-cholesterol, LDL-cholesterol and HDL-cholesterol were 3.9, 1.5, 4.3, 1.8 and 1.3 times, respectively. As compared to non-pregnant control subjects, IOP in second (IP < 0.02) and third (P < 0.001) trimesters were significantly lower. Intraocular pressure and plasma lipid changes were found to be independent of heart rate, systolic and diastolic blood pressure, plasma osmolarity and hemoglobin concentration. These findings suggest that hyperlipidemia is common in pregnant females with ocular hypertension. Furthermore, there occurs an inverse relationship between plasma lipids and IOP with advancing pregnancy.

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