Aziz Marjan Khatiak, Habib Ullah Khan, Ihsan Ullah Mashud, Syed Humayun Shah, Bushra Ashiq.
Antimicrobial sensitivity pattern of urine isolates from asymptomatic bacteriuria during pregnancy.
Biomedica Jan ;22(1):67-70.

Screening women for asymptomatic bacteriuria (ASB) on the first antenatal visit is a part of standard 0bstetric care. Treating women with ASB decreases the chances of maternal and f0etal complications. This study was conducted to find out the spectrum of urine path0gens and their drug susceptibility pattern for ASB during pregnancy. The study was conducted in the Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre Karachi, from September 2001 t0 March 2002. Two hundred and ninety women, apparently normal with confirmed pregnancy, were registered. A voided midstream urine specimen was collected and cultured. A significant growth i.e. >= 105 organisms/ml was identified with Analytical Profile Index 20 tests for identification of Enterobacteraceae (API-2o-E) and for Gram positive cocci by other standard methods. The prevalence of ASB was found 6.2%. Antimicrobial sensitivity was determined by disc diffusion Kirby Bauyer method after matching the turbidity with 0.5 McFarland`s standard. Most of the recommended drugs were found to have encouraging results, h0wever, Escherichia coli showed 66.67% resistance to ampicillins and sulph0namides. Enterobacters sh0wed 100% resistance to ampicillins, cephalosporins and nitrofurantoin. Staphyloc0ccus saprophyticus showed 66.67% resistance to ampicillins and sulph0namides. It was c0ncluded that detection 0f ASB during pregnancy and appropriate use of antimicrobials is 0nly p0ssible after culture 0f urine. Empirical anti-microbial therapy cann0t be relied up0n because 0f p0ssible risk of resistance.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com