Naveed R Qureshi, Naveed Aslam, Aziz Fatima.
Efficacy of Prophylactic Ciprofloxacin in the Prevention of Spontaneous Bacterial Peritonitis.
Pak J Med Sci Jan ;17(2):112-5.

Objective: To assess the efficacy of giving prophylactic ciprofloxacin for the prevention of spontaneous bacterial peritonitis (SBP) in cirrhotics. Design: A prospective study of eighty (80) patients suffering from liver cirrhosis with ascites. Setting: Medical Unit-III, Services Hospital, Postgraduate Medical Institute, Lahore, Pakistan. Main Outcome Measures: Whether or not spontaneous bacterial peritonitis develops during a follow-up of one year. Results: From the ciprofloxacin group, seven patients (17%) developed spontaneous bacterial peritonitis while in the control group, sixteen patients (40%) developed spontaneous bacterial peritonitis during follow-up of one year (p=0.048). At one year follow-up, the probability of recurrence was 28% in the ciprofloxacin group and 78% in the control group. Conclusion: These results indicate thatlong-term selective intestinal decontamination with ciprofloxacin is effective and safe in preventing spontaneous bacterial peritonitis recurrence.

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