Aslam Nagi, Iqbal Ahmad Memon, Shagufta Yasmeen.
Hereditary Spherocytosis: reporting two cases.
Pak Paed J Jan ;29(1):41-5.

Hereditary spherocytosis (HS) is a familial hemolytic disorder with marked heterogeneity of clinical features, ranging from an asymptomatic condition to fulminant hemolytic anemia. The morphologic hallmark of HS, is the microspherocyte, which is caused by loss of membrane surface area, and an abnormal osmotic fragility in vitro. Investigation of HS has offered important insights into the structure and function of cell membrane and the role of spleen in maintaining red blood cell (RBC) integrity. An intrinsic genetic defect causes defect in membrane proteins.

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