Asher Fawwad, Rashida Qasim, Zafar Iqbal Hydrie, Abdul Basit, Zahid Miyan, Asma Gul.
Correlation of fasting insulin resistance indices with clinical parameters of metabolic syndrome in type 2 diabetic subjects.
Pak J Med Sci Jan ;22(4):433-7.

Objectives: To identify the insulin resistance by various available insulin resistance indices and to see their correlation with clinical parameters of metabolic syndrome in type2 diabetic population. Methods: All type 2 diabetic subjects having age 30 years or more were selected with exclusion criteria (hepatic, renal or cardiac impairment). Insulin resistance was assessed by components of metabolic syndrome as defined by ATP III and by using fasting insulin resistance indices i.e. HOMA, QUICKI and McAuley. The correlation between clinical parameters of metabolic syndrome and insulin resistance indices were seen by calculating Pearson`s coefficient. Results: One hundred eighteen subjects were selected (62.4% males and 37.6% females). Mean BMI was 27.8±4.9kg/m2. Mean systolic B.P was 129.7±19.7. Mean diastolic B.P was 80.9±10.8. Mean LDL level was 103 ± 27.6. Mean HOMA was 4.1. Mean QUICKI index was 0.3276. Mean McAuley was 6.79. The results indicate that various Insulin resistance indices have strong and significant correlations in between them but not significantly correlated with all clinical parameters of metabolic syndrome. Conclusion: Correlation of fasting insulin resistance with clinical parameters of metabolic syndrome is lost when people develop diabetes.

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