Fahad Abdullah Alzamil.
Chemokines and their association with pediatric diseases.
Pak J Med Sci Jan ;22(4):496-502.

The knowledge about chemokines and their receptors activity is an essential need of health care professionals. Chemokines represent a superfamily of small, inducible, secreted, proinflammatory cytokines involved in a variety of function in leukocyte trafficking, recruiting, and recirculation. The purpose of this review is together and highlights the different studies concerning with chemokines and their potential effects with various diseases. Chemokines play a significant role in many pathophysiological processes such as inflammation, allergic responses, autoimmune diseases, angiogenesis and tumor growth. In addition, particular chemokines have been reported to act on hematopoietic progenitor cells, influence wound healing and have a close assoiciation between their receptors and certain human diseases. It is important to know the biological characteristics of chemokines and their receptors activity. It has been also observed that there is a close assoiciation between chemokines, chemokine receptors, cells and certain adult and paediatric diseases. In additon, chemokines play a significant role in many pathophysiological processes such as inflammation, infectious, allergic response and autoimmune diseases. This is a review article.

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