PakMediNet Discussion Forum : Medical Research in Pakistan : Clinical trial on Hepatitis C
i started a clinical trial of a herbal product on hepatitis C before designing any protocol & planning the study properly. study is going fine. what i will have to do to make this study acceptable and publishable.
Posted by: sannanpk Posts: 3 :: 05-09-2001 :: | Reply to this Message
What kind of clinical trial is it ?
Which Herbel medicine are you using and whats your place of research ? What is your sample size, methods etc ...
Posted by: docosama Posts: 333 :: 05-09-2001 :: | Reply to this Message
quote:
docosama wrote:
What kind of clinical trial is it ?
Which Herbel medicine are you using and whats your place of research ? What is your sample size, methods etc ...
Posted by: sannanpk Posts: 3 :: 09-10-2001 :: | Reply to this Message
Kindly tell us about the results of your herbel medicines.
Posted by: docosama Posts: 333 :: 09-10-2001 :: | Reply to this Message
why have my comments been deleted!!I said this was a unethical trial & would have led to a criminal prosecution in a civilised country.i am entitled to my views & stand by them.
Posted by: zhussain Posts: 23 :: 24-11-2001 :: | Reply to this Message
Sir
Avoid writing anything if you cant encourage or say some good words for anybody.
How do you know its an unethical trial ? Have you investigated it ? or you are also into same sort of trial ?
And what kind of criminal prosection are you talking about ? Is doing a new research in any field related to medicine, an unethical thing ?
There is still a lot to be in done for Hepatitis C. If somebody is using Herbel medicines, why should he be stopped for that ?
You seemed an Anti-Pakistani, you kept on discouraging things in all your postings.
Posted by: docosama Posts: 333 :: 27-11-2001 :: | Reply to this Message
why have you deleted my answer mr docosama?
Posted by: zhussain Posts: 23 :: 06-12-2001 :: | Reply to this Message
i will repeat therefore that such a trial of a herbal potion by a quack is unethical & unscientific .he is depriving people of established management for the condition by experimenting with their lives on a silly unscientific herbal potion which has not been tested.
[Edited by docosama on 12-06-2001 at 04:40 PM GMT]
Posted by: zhussain Posts: 23 :: 06-12-2001 :: | Reply to this Message
Sir
I have also read your discouraged comments. Please dont say anything when you dont know anything. The person who is doing research has taken consent from the patients and following scientific ways to do the research. His research will publish also.
Please discuss good things over here. Administrator will might delete your account and will ban you as well.
Posted by: yasir Posts: 90 :: 06-12-2001 :: | Reply to this Message
Mr Yasir the aim of this forum should be to encourage proper & ethical research.How can you justify a trial of a untested herb on patients & deprive them of established & useful medical treatment.In the words of the researcher himself he has not even designed a trial.If Godforbid you had hep.c would you like to be deprived of standard & established medical treatment & be put on a substance of no proven benefit or scientifically a reason to believe it will work.The right thing for mr docosama to do would have been to educate the individual as to how research is planned & carried out ethically & that would have been a great service.But perhaps mr docosama needs some educating too.
Posted by: zhussain Posts: 23 :: 06-12-2001 :: | Reply to this Message
Good Answer Sir.
Just tell me what is the treatment of Decompansated Cirrhosis other than Liver Transplant which poor people cant afford ?
Posted by: shakil Posts: 5 :: 07-12-2001 :: | Reply to this Message
quote:
shakil wrote:
Good Answer Sir.
Just tell me what is the treatment of Decompansated Cirrhosis other than Liver Transplant which poor people cant afford ?
Posted by: zhussain Posts: 23 :: 21-02-2002 :: | Reply to this Message
Sorry for the delay in replying.
You are assuming that all the poor patients in this obnoxious trial(if you can call it that)have end stage liver disease---the gentleman doing this so called trial does not mention that!
Posted by: zhussain Posts: 23 :: 21-02-2002 :: | Reply to this Message
The discussion has gone in a wrong way and the original question has not been properly answered. The "research" as is being carried out can only be published as a letter to editor only when a related article has already appeared in a journal. In such a situation, it will be the experience of the writer and not the research.
One can carry out the research (and draw conclusions) in a way he likes. But for publication, it must follow a rigidly prescribed routine. The case being discussed falls under a clinical trial. In such cases if only one drug is to be tested then a minimum of two groups are necessary. One group of patients should receive placebo, preferably consisting of the base in which the drug is prepared. The other group will receive the drug treatment. The patients should be allotted to the two groups in a proper random way. They should be explained about the trial and should volunteer for the treatment. The results of the treatment should be measured by another person who does not know the grouping of the patients. Finally when the results are tabulated, then it must be determined whether the observed effect is actual or it could be by chance.
Without this protocol, treating 'x' number of patients with 'y' drug(s) and reporting 'z' results cannot be published.
Posted by: saeedkhan Posts: 7 :: 26-03-2002 :: | Reply to this Message
Any research should first be approved by a ethical committee to make sure the research is ----------well ethical!!Does such a body of experts exist
Posted by: zhussain Posts: 23 :: 24-04-2002 :: | Reply to this Message
I agree with Saeedkhan that discussion is going in wrong way. We should be cool and polite. Research is very difficult and tiring job. You have to be answerable for each and evry step you take. I think the reserach work should be properly planned fulfilling all the prerequisites. The approval of an ethical apptoval is mandatory specially in interventional trial. Having said that ,it is a fact that we face problems in getting approval from ethical committees as the existing committees{if any } are very lethargic in replying. What we need are ethical committees at the distt level, teaching hospital and provincial level.
Posted by: lachvi Posts: 47 :: 26-04-2002 :: | Reply to this Message
I'm confused a bit here. Is the trial on Hepatitis C related Cirrhosis? or is it on patients with Cirrhosis? If these patients are so decompensated that the alternative is liver transplant, how are they being kept alive?
Posted by: chameed Posts: 173 :: 26-04-2002 :: | Reply to this Message