Saima Iqbal, Sadia Hanif, Zaib Un Nisa, Ambreen Shabbir, Khizera Anwar, Nighat Afridi.
Comparison of the Effectiveness of Oral Progesterone and Micronized Progesterone Pessary in Reducing the Spontaneous Preterm Birth Incidences.
Pak J Med Health Sci Jun ;17(2):395-395.

Objective: The purpose of this study is to compare the effectiveness of oral progesterone and micronized progesterone pessary in reducing the spontaneous preterm births incidence. Study Design: Randomized controlled trial Place and Duration: Gynaecology and Obstetrics Department of Combined Military Hospital, Peshawar from January 2021 to December 2021. Methods: Total 112 pregnant females were presented in this study. Included females were aged between 18-45 years. After taking informed written consent, detailed demographics of enrolled cases included age, BMI, parity and gestational age was recorded. Females were divided in two groups. Group I received oral progesterone in 56 females and group II received micronized progesterone pessary. Post-operative outcomes among both groups were assessed. SPSS 23.0 was used to analyze all data. Results: Among 112 cases, 35 (31.3%) had age 18-25 years, 45 (40.2%) females had age 26-35 years and 32 (28.6%) cases had age 36-45 years. 64 (57.1%) patients had BMI <25kg/m2 and 48 (42.9%) cases had BMI >25kg/m2. Mean parity in group I was 2.5±1.23 and in group II parity was 1.72±3.16. Mean gestational age of the patients in group I was 33.16±10.42 weeks and in group II mean gestational age was 34.17±8.23 weeks. Frequency of c-section in both groups were higher as compared to vaginal delivery with p value <0.003. Mean time of prolongation of pregnancy in group I was 18.22±6.33 days and in group II mean time was 30.7±5.47 days. We found that micronized progesterone cyclogest pessary was effective in terms of reducing NICU admissions, maternal systemic complications, preterm C-section, tocolysis use, side effects, intraventricular haemorrhage and perinatal mortality as compared to oral progesterone. Conclusion: Preventive micronized progesterone pessary was found to be more effective than oral progesterone (dydrogesterone) in reducing premature birth among women at  high-risk of premature delivery. Keywords: Oral Progesterone, Micronized Progesterone Pessary, Preterm Birth, Side Effects

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