Muhammad Nadeem Akbar Khan, Muhammad Dilawar, Farooq Ahmad Khan, Saadia Sultana, Aamir Ljaz, Uzma Naeem, Zulfiqar Ali Amin.
Impaired fasting glucose individuals: their response to oral glucose challenge.
Pak J Pathol Jan ;17(4):151-5.

Objectives: To determine the frequency of Impaired Fasting Glucose (IFG) individuals in symptom free adults and their 2-h PG (two-hour plasma glucose) concentrations in standard Oral Glucose Tolerance Test (OGTT) with 75-g glucose. Design: Non-interventional observational study. Place and duration of study: The study was conducted from July 2004 to Dec 2004 at the department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology. Rawalpindi. Patients and methods: Fasting plasma:glucose (FPG) of 859 symptom free adults was checked. Of them, 344(40%) were found to have IFG, who were subjected to standard OGTT with 75-g glucose and their 2-h PG results were recorded. Results: Frequency distribution of FPG of 859 symptom free adults showed, 455(53%) were Normal Fasting Glucose (NFG <5.6mmol/l), 344(40%) were IFG (5.6-6.9mmol/l), and 60(7%) were diabetics (>7.0 mmol/l). The difference in frequency of three groups of FPG was statistically significant (p<0.0001) Of 344 IFG individuals, who were subjected to standard OGTT, 182(53%) had Normal Glucose Tolerance (NGT), 127(37%) were Impaired Glucose Tolerance (IGT) and 35(10%) were diabetics. The difference in frequency of the three groups was statistically significant (p<0.0001). Conclusion: A significantly large number of asymptomatic adults are suffering from` IFG in our set up. When IFG individuals are subjected to 75-g OGTT, their 2-h PG results showed about one third have IGT and also a significant number of IFG individuals are found to be patients of diabetes.

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