Shahid Abbas.
Regression of Left Ventricular Hypertrophy with various Anti-Hypertensive agents.
Pak Armed Forces Med J Jan ;47(2):15-20.

The hypertrophy of the left ventricular (LV) myocardium produced by hypertension is of a multifactorial genesis. Besides the mechanical stress of hypertension on the left ventricle there are many other factors also which are responsible for the production of left ventricular hypertrophy (LVH). Lowering of the blood pressure alone therefore may not completely reverse the LVH. Since LVH associated with hypertension carries significantly increased morbidity and mortality in these patients, it is important not only to lower the blood pressure (BPI but also to decrease the LV mass to normal limits. This study compared the effects of perindopril, amlodipine and atenolol over a period of 1 year on the LV mass in patients with hypertension, in whom these drugs produced similar degree of lowering of BP. Thirty patients were studied in each of the three treatment groups. Initial BP, initial LV mass and the BP response was similar in all the three groups. There was a statistically significant (p<0.05) decrease in the LV mass only with perindopril at 6 months and with both perindopril and amlodipine at 12 months, but not with atenolol. Moreover the regression in LV mass produced by perindopril was greater than that with amlodipine, though not to statistically significant level.

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