Farrukh Naheed, Hassan Fatima Jaffery.
Estrogen replacement therapy to treat climacteric symptoms in surgical menopausal women.
J Surg Pak Jan ;12(1):23-6.

Objective: To determine the role of estrogen replacement therapy (ERT) in the alleviation of climacteric symptoms in surgical menopause. Study Design: Quasi experimental study. Patients & Methods: Two years study was conducted from March 2000 to September 2003, from out patient department, of “Menopausal Clinic” at Jinnah Postgraduate Medical Centre, Karachi. Hundred surgical menopausal women were selected who presented with severe climacteric symptoms. After detail history and examination, all patients were investigated to exclude the risk before institution of ERT. Results: Intervention of ERT produced marked improvement in most common symptoms i.e. hot flushes and sweating in 92.9% (C.I. 78 – 98.9 – p value 0.001) and depression in 81% improved (C.I 56.5 – 95.2 – p value 0.001). Vaginal dryness improved in 88% (C.I. 64.9 – 98.6). Insomnia improved 53.3% (C.I. 54.4 – 97.4). Less common symptoms like dysuria also showed marked improvement after oral estrogen replacement therapy, minimum after 6 months till 2 years of therapy. Conclusions: Short term (<5years) ERT might be considered for relatively small group of women who experience severe disruptive vasomotor symptoms or severe atrophic vaginitis. But more similar large studies need to be performed for more generalized therapeutic recommendation of ERT.

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