Syed Saud Hasan, Shaheen Sharaf Shah, Mahboob Wagan, Aftab Turabi, Muhammad Yousaf Salat.
Effects of Verapamil on central & peripheral airway function of guinea pigs.
Professional Med J Jan ;13(4):533-7.

Introduction: Calcium ions play an important patho-physiological role in allergic reactions. It is therefore likely, Ca++ antagonist, Verapamil may modify the allergic broncho-pulmunary responses. Isolated preparations were used to examine the direct action of the Verapamil on bronchial and pulmonary smooth muscles. Material and Methods: The bronchial spirals and the lung parenchymal strips were prepared that enabled the investigation of the action of agents on peripheral and central airways in the same species and compare the responses. To observe the effects on ovalbumin sensitized guinea pigs bronchial and lung parenchymal tissue after 10 minutes exposure of verapamil in different concentration and to evaluate the antagonistic / inhibitory effect on antigen induced contractile responses. Resulfs: The data showed that inhibition of antigen induced response with verapamil was better in central airways than to peripheral airways smooth muscle. Conclusion: Concluded from this study that verapamil can influence both central and peripheral airway function by modulating antigen induced bronchoconstriction; however, it leaves query regarding the importance of this activity in clinical set up.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com