Hamad M S Al Ali, Abdel Kareem Durgham, Nawaf Al Khazalel, Hisham Rashdan.
Creatine Kinase, Creatine Kinase B - Subunit and ECG Study in Acute Myocardial Infarction.
J Coll Physicians Surg Pak Jan ;11(11):684-8.

Objective: To determine the significance of total creatine kinase (CK) and its isoenzyme (CK-MB) measurement as well as electrocardiography (ECG) in the diagnosis of acute myocardial infarction. Design: This was a descriptive study. Place and Duration of Study: The study was conducted at King Hussein Medical Centre, Jordan, that extended over four months period. Subjects and Methods: We evaluated a diagnostic strategy by studying a group of 300 patients suspected of having an acute myocardial infarction and 300 individuals as control. Individuals studied were between 37-75 years of age. Serum total CK, CK-MB were determined every 12 hours by CK, CK-MB. NAC activated methods (Boehringer Mannheim`s) using Brioten 10 semiautoanalyzer. Results: In acute myocardial infarction (AMI) patients, the mean value of total CK as well as CK-MB was greater than normal range in both sexes. The maximum peak was found to be 8 hours for males and 12 hours for females, after the onset of myocardial infarction. Antero septal myocardial infarction (in males), was almost twice as common as inferior myocardial infarction and much more common than high lateral or antero lateral myocardial infarction. This study demonstrated that measurement of total CK, CK-MB and ECG is currently the test of choice to confirm the diagnosis of an AMI. This strategy is adequate and cost-effective for the diagnosis of AMI as well as in identifying people at high risk of AMI. Conclusion: Measurement of total CK and CK-MB, as well as performing ECG, is an effective way of identifying patients at high risk of A2.

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