Afhami M R, Hasanzadeh Salmasi P, Rahimiye Panahea J.
Dropridol and Metoclopramide in the prevention of postoperative nausea and vomiting.
Rawal Med J Jan ;32(2):125-7.

Objective: To asses the efficacy of droperidol and metoclopramide for prevention of post operative nausea and vomiting (PONV) in patients undergoing ophthalmic surgery under general anesthesia. Materials and Methods: This is a double blind, placebo controlled randomized study performed at Tabriz University of Medical Sciences, Tabriz, Iran on one hundred and fifty ASA physical status 1 or 2 (classification of physical status by American Society of Anesthesiologists) adult patients undergoing elective ophthalmic surgery (cataract). All the patients were anesthetized with endotracheal intubation and received either metoclopramide 0.15mg/kg, droperidol 0.02mg/kg or placebo approximately 10-15 minutes before extubation. Direct observation of the vomiting by the nurse in the Post Anesthesia Care Unit (PACU) for at least 2 hours and in the ward for 24 hours was made. Chi-square test with descriptive statistical method was employed for data analysis. Results: There significant difference between groups received pharmacological intervention and placebo group (P<0.01). However, droperidol in comparison to metoclopramide significantly decreased incidence of PONV (P<0.02). Conclusion: Droperidol 0.02mg/kg seems to be suitable for the prevention of PONV without significant sedative effects. (Rawal Med J 2007;32:125-127).

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