Zahid Hashmi, Ghazala Bashir, Perveen Azeem, Shakeel Shah.
Effectiveness of intra-venous iron sucrose complex versus intra-muscular iron sorbitol in iron deficiency anemia.
Ann Pak Inst Med Sci Jan ;2(3):188-91.

Objective: To determine the effectiveness and tolerability of intravenous iron sucrose complex in the treatment of iron deficiency anemia in pregnant and postnatal women Place & Duration of study: This randomized controlled study was conducted at Zanana Hospital attached with Gomal Medical College & Hashmi Maternity clinic Dera Ismail Khan from September 2005 to March 2006. Patients & Methods: Eighty patients with gestational age of 12-36 weeks from antenatal clinic and 20 patients after post-partum haemorrhage with anemia were selected and divided randomly into two groups of 50, each group having equal number of pre & post natal patients. Group A received intra-venous treatment of iron sucrose and Group B was administered intra muscular iron sorbitol. Results: Group A had mean hemoglobin concentration of 7.3 ± 1.1g/dl and group B had 7.9 ±0.9 g/dl haemoglobin concentration before the start of therapy. The patients were reassessed three weeks post therapy which showed a total rise of 2.6gIdi (group A) and 1.2g/dl (group B). Second assessment was done after six weeks which showed a total rise of 4.6g/dl (group A) and 2.2g/dl (group B), respectively. Target haemoglobin level i.e.11g/dl was achieved in 80% in group A and 20% in group B. Blood transfusion was not required in any group. Conclusion: Intravenous iron therapy is safe. convenient and more effective than intramuscular iron therapy in the treatment of iron deficiency anemia during pregnancy. It can minimize blood transfusion in postnatal women.

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