Aneel Aslam, Adeel Aslam, Wasima Talat.
Pregnancy induced hypertension; anti-hypertensive therapy in a study using single drug versus multiple drugs.
Professional Med J Jan ;14(1):30-2.

Objective: To assess the stress response in severe pregnancy induced hypertensive patients on different drug regimen during preoperative and postoperative period. Sample size: 40 patients. Study Design: Comparative study. Place: CMH Kharian and WT Obgyne (Pvt) Ltd. Multan. Duration: June 2004 to January 2005. Patients and Methods: 40 patients of severe pregnancy induced hypertensives were induced in this study. 20 patients were placed on a single standard anti-hypertensive i.e. alpha methyldopa and 20 were put on a combination of alpha methyldopa with long acting nifedipine or amlodipine. Both these groups underwent caesarean section. The stress response in both these groups was carefully analyzed and compared with a special note on any untoward effect on the mother or fetus. Results: The results from this trial clearly demonstrated that patients on combined drug therapy showed better stress response during perioperative and postoperative period. Conclusion: In severe PIH patients undergoing caesarean section good feto-maternal outcome was obtained on combination antihypertensive drug therapy as compared to patients receiving single anti-hypertensive drug.

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