Shamaila Ijaz Haider, Ijaz Haider.
Comparative trial of selective serotonin reuptake inhibitors in depression.
Pak J Med Sci Jan ;17(4):237-9.

Objective: To compare efficacy of sertaline and imipramine in depressed patients in 50mg twice-daily dose. Design: A comparative open trial of both drugs was carried out in 92 depressed patients attending as out patients. Setting: Out patients attending Department of Psychiatry, Jinnah Hospital, Lahore. Results: 40 patients received sertaline and 52 received imipramine in 50mg twice-daily dose for 4 weeks. 33 patients in sertaline group and 40 patients in imipramine group completed the trial; 24 (72%) and 29 (72%) in each group showed improvement whereas 9 (27%) in sertaline and 11 (27%) in imipramine showed no change. Conclusion: Both sertaline and imipramine are effective in the treatment of depression.

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